Does vitamin B3 (Niacin) "lower" the seizure-threshold of some anti-seizure medications?

I know that Evening Primrose Oil and Barage Oil lower the seizure-threshold, causing a patient on anti-seizure medication to have more seizures.

What I am concerned about, is the side-effect that is produced by taking Niacin. This side-effect is known as the "Niacin-Flush" and has similar sensations to an aura or seizure.

If Niacin does NOT lower the seizure-threshold, perhaps the STRESS of the "Niacin-Flush" may bring about seizures in individuals with a seizure disorder.

Please cite your source of information.

Thank you for aiding me in this important research.

Niacinimide the synthetic version on Niacin is considered "no-flush"
Perhaps you can correlate data from Niacinimide and find out if it is in fact the "flush" that is producing more seizures.

Thank you Figato for your well thought out recommendation.
I will see if there IS a difference between Niacinimide and Niacin forms of B3.

With MUCH appreciation, 专讛 驻谞讬谞讛褨讗 Report It

There are no reports of any drug interactions concerning seizure medication and niacin in the literature available through MEDLINE. There have been reports of drug interactions with regular release niacin and statins (used to lower cholesterol) when Rx time-relase products should have been used. Also reports of interactions with certain blood pressure meds (significant blood pressure drop). The flushing experienced should not be so great to cause "stress" to the point of provoking a seizure. The blood levels of the seizure meds should be tested to insure proper dosing.