Can anyone(genius) explain briefly about why there is no vaccines on AIDS and MALARIA?

there is no a vaccine for HIV disease cause the virus destroy the immune system of the body so if we made a vaccine may be the person will get the disease inside of gaining the immunity from the disease ,if they just find how the cure this virus I'm sure they will made a vaccine
and for malaria there is avaccine used when the person decided to travel to area the disease spread there

You must be wealthy to purchase those types of vaccines, they are out there but our government will not tell us.

Malaria is a parasite, for which there is no way to vaccinate; only preventing the parasite from being able to grow in the bloodstream will prevent someone from contracting it if they are bitten by a mosquito carrying the parasite.

HIV/AIDS is more complicated; it doesn't act in the way a "normal" virus acts, so building immunity to it doesn't work either. It shuts down the very system - the immune system - that builds immunity, so there has to be a way to keep the immune system functioning while still allowing it to react to a vaccine that is made from a virus that shuts it down, and that's going to take some time.

1. AIDS-
AIDS is a disease caused by the HIV virus. It is a retrovirus, and hence has the capability to mutate frequently, hence developing a vaccine aginst it is difficult.

2.Malaria-
I thought Malaria could be prevented by the Quinine vaccine.

Nature has always kept a premium on reality, especially human challenges against it. The world humanity existence is based on certain principle which is not aware to all, and which can not be understood other than principally. Start with the point that 'Energy is controlled by emotions, irrespective of circumstances'. Energy does not born nor die, but transforms here and there in the Universe. There is always an emotion behind every consumption of the energy and again it restores to the previous stage - say, water evaporated from ocean falls by rain and flows by river and reaches the ocean - Aids and such diseases - a lot still untraced - are there without any medicines even. Same way, psychologial diseases also. How can the humanity overcome this - only way is God.

These diseases are caused by viruses. It is disputed whether a virus should be categorized as living or non-living, because of the absence of the "cell", which is considered as the basic building block of life. Yet it possesses nucleic acid and respond to their environment, like living organisms, in a limited fashion.

Viruses can only replicate themselves by infecting a host cell and therefore cannot reproduce on their own. Because viruses use the host cell to reproduce and also reside within them, they are difficult to eliminate without killing the host cell.

And therefore, its not possible to cure or vaccinate against viruses.

I only know of the vaccine for AIDS.
http://www.iavi.org/ is the site of the International AIDS Vaccine Initiative Group.
From their own site:
"Treatment advances have yielded important new AIDS therapies, but the cost and complexity of their use put them out of reach for most people in the countries where they are needed the most. In industrialized nations where drugs are more readily available, side effects and increased rates of viral resistance have raised concerns about their long-term use. "

So basically, it exists but like everything else its hard to get to the third world masses. Also, its still fairly experimental (unknown side effects). All medical and pharmaceutical products have to meet strict FDA regulations in the US and comprable international regulations throughout the world.

It's not for the lack of trying. To sum it up in just a few words, it's been very difficult to create a vaccine for AIDS because the drugs that can kill the virus will also kill the cells in the body that we are trying to keep alive. Scientists are trying to strike a balance between killing the virus and not killing the person.

As for Malaria, it is a similar situation. Malaria is not a virus. It is caused by a parasite that lives in the blood stream and liver of it's human host. The drugs that can kill the parasite will also kill people. The cell structures are similar in the human and the parasite. We are trying to kill "eukaryotic" cells in the parasite, but eukaryotic cells are the same in both animals, and they therefore respond the same to any chemicals.

They are from complexive viruses. But soon they will find medicine for AIDS and Malaria. But at that time, one more disease will be coming which is not curable. This is an never ending process

Many viral diseases lack efficient vaccines - as I understand it this is mainly due to the rate of mutation of each virus thus rendering any developed antibodies ineffective.

Add to that... that some single diseases can be caused by more than one strain or type of virus (more opponents for the vaccine),
And ... some viruses had developed effective means of hiding from your immune system until suffient in number to overwhelm your system

AIDs and maleria might be with us for some time yet

I hope my poor explanation helps ... maybe someone more medical might clarify or add anything I've missed

Regarding the terms no VACCINE- Process is going on for making the same, Several team of Research Scientists are busy in that, Very soon they will be available in the market.
These diseases are not discovered since very long, and so the scientists have not yet succeeded in getting a vaccine to prevent it.
We can only prevent by few safety measures.

well to start with malarial parasite has many stages in the host body i.e man& mosquito.every stage has diff. structural properties.now the parasite has also become resistant to cloroquinine.all the 4 malarial parasites can dominate a host body in groups like in p.falciparum`s case.so its dificult to develop vaccine for them.the only way is to control mosquito.
n aids well its retro virus.recent studies have shown that circumscission can lower hiv spread by wooping 30%.this is due to the fact that hiv virus attacks langhen cells in prepuce so circumscission can lower the risk.vaccine ,aids has a complex glycolipid structure and attanks cd4+ cells vaccine production is difficult as they have very complex structure in every stage of their life.study is on lets hope for the best

To help answer your question, currently there are no vaccines for either malaria or AIDS. Scientists, doctors, and pharmaceutical companies alike are in the beginning processes of doing reserach, conduncting studies, and creating vaccines for malaria and perhaps HIV/AIDS.

Malaria affects 10 percent of the world鈥檚 population. It kills about 2 million children every year. That is one every 15 seconds. Anti-malarials like the quinine-based drugs have to be taken regularly, and are too costly for much of the third world. What is needed is a vaccine. Australian scientists are at the forefront of the international effort to produce such a vaccine. They have made several breakthroughs, and are getting closer to providing relief from the devastation of malaria.


An experimental vaccine that attacks the malaria parasite in its early stages prevents a significant number of malaria cases, and should move closer to licensing and widespread use, according to a new review of recent studies.

Among children in Mozambique, where malaria is common, the new vaccine -- called RTS,S -- reduced the number of clinical malaria episodes by 26 percent for up to 18 months after vaccination. There were 58 percent fewer severe episodes among the children over the same time period.

The vaccine also reduced the number of clinical malaria episodes in partially immune men in Gambia by 63 percent after they received a booster shot a year later, say co-authors Patricia Graves, Ph.D., and Hellen Gelband.

The RTS,S vaccine, which is still being tested, "showed extremely promising results," said Graves, of EpiVec Consulting, a research firm in Atlanta.

HIV/AIDS vaccines are still in clinical and preclinical trials.

http://www3.niaid.nih.gov/research/topic...
www.iavi.org

Four other trial vaccines that target early-stage malaria did not have any significant effect on the parasite, the researchers said.

The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

In a second Cochrane review, Graves and Gelband analyzed studies of a vaccine that targets malaria at a later stage of development, after the parasite has entered the bloodstream.

The experimental "blood-stage" vaccine called MSP/RESA or Combination B "shows promise as a way to reduce the severity of malaria episodes," but was most effective against one particular strain of falciparum malaria in Papua New Guinea," Graves said.

"In light of this proof of principle, the vaccine should undergo further development to improve its effectiveness," she added.

By targeting two different stages in the malaria parasite's lifestyle, the two types of vaccines may accomplish different ends, the Cochrane reviewers say.

Vaccines such as RTS,S "usually aim to completely prevent infection, while blood-stage vaccines aim to reduce, and preferably eliminate, the parasite load once a person has been infected," Graves said.

Many researchers think multistage vaccines that recognize and latch on to different proteins produced by the parasite during its life cycle "are likely to be most effective," Graves said.

The October 8 issue of the Washington Post Magazine details the efforts of scientists at Walter Reed Army Research Institute, who codeveloped the RTS,S vaccine with the drug company GlaxoSmithKline.

"The idea is that RTS, S would work like a Patriot missile system," said Col. Gray Heppner in the Post article. "All those parasites will be coming in like missiles, and RTS,S will be shooting them down."

There is a range of support for different vaccine types among malaria researchers, said Walter Brandt, Ph.D., a senior program officer at the Malaria Vaccine Initiative, a vaccine development program of the nonprofit global health organization PATH.

While some researchers think malaria will be prevented eventually with the right combination of early-stage vaccines, "others believe there is no 100 percent vaccine, which means we have to have some kind of blood-stage vaccine in the mix," Brandt said.

However, MVI is "neutral" in this debate, Brandt said, adding that his organization is more concerned with identifying and promoting effective vaccine candidates of any type.

The Cochrane review of early-stage malaria vaccines included 11 studies and more than 3,000 participants. The blood stage review included five studies and 217 people. Arm pain and swelling were the most common side effects reported in both vaccine reviews.

"Serious side effects were very rare with either of the effective vaccines," Graves said.

In short, many HIV vaccines have been tested but none are clinically effective because the virus mutates to evade the immune response.

Malaria is caused by a protozoan parasite that evades the immune response by residing in red blood cells and the liver. As the previous answer pointed out, vaccines are being developed for both diseasses, but finding an effective vaccine is not as easy as the public percieves it to be.

The malarial parasite exists in many different stages, in the liver as well as the red blood cell and in the mosquito. All these forms have different antigenicity. Therefore, it is difficult to make a vaccine which is effective against all these stages. Research is still going on, but a successful vaccine has still not been discovered.