Are there any studies/clinical trials on the (possible?) prophylactic effect of the NSAIDs on HIV infection?

Ibuprofen preventing HIV infection? NSAIDs as a prophylactic regimen against HIV infection? are there any medical studies / clinical trials on this?

http://ipath.org/10.htm

Aspirin (ASA) Has a Potent Effect Increasing CD4 Counts in HIV Disease.

A Comparison of ASA to AZT (Zidovudine) historic data.


Howard S. Armistead

Aspirin (ASA) is a well known anti-inflammatory, and a potent antioxidant that acts primarily through inhibition of nuclear factor-kappa binding (NF-魏B). As an NF-魏B inhibitor, ASA significantly inhibits tumor necrosis factor-alpha (TNF-伪). ASA, an aspirin analogue, has been shown to decrease HIV-1 antigen by 65%.

In a controlled clinical trial of ten HIV-1 positive subjects, 1.2gr. of ASA per day increased CD4 counts an average of 30.3% at six months, 83.2% at nine months, and 36.3% at twelve months.

A review of historic data from clinical trial results published between 1987 and 1991, shows that Zidovudine (AZT) increased CD4 counts 鈥渢ransiently鈥? with a peak average increase in CD4 of approximately 35% taking place at between four and twelve weeks, falling back to baseline values on average at about five months.5-7 The longest AZT was shown to increase CD4 count above baseline was 36 weeks (8.5 months), when only 300mg AZT per day was used.7 CD4 declined 25% on average from baseline at one year using AZT monotherapy, compared to aspirin鈥檚 average 36% increase in CD4 at one year.

In conclusion, comparing their peak increase in CD4 cells, ASA has been shown to increase CD4 more than twice as much as AZT and is better able to sustain this increase. At the one-year point, while the CD4 count of those on AZT monotherapy decreased 25% below baseline levels, those taking aspirin maintained an average 35% increase in CD4. This reflects the fact that aspirin possesses not only anti-retroviral activity as an NF-魏B inhibitor, but it can also increase immune function, again through inhibition of NF-魏B.

This review comparison demonstrates that ASA is a superior drug to AZT in the treatment of HIV-1 related immune deficiency. ASA has far fewer negative hematological side effects than AZT and it possesses significant cost advantages. This suggests that the NF-魏B inhibitor class of drugs, some potentially much more potent than aspirin, may have been overlooked in the rush to new HIV drug development. The use of NF-魏B inhibitor drugs may offer new opportunities to help solve the challenge of HIV/AIDS in the developing world.

I haven't heard of any but what effect exactly would an anti -inflamitory have on a retrovirus?